Kumagai Y, Fujita T, Maeda M, Yamamoto A, Amano H. Pharmacology and safety of TAS5315, a Bruton tyrosine kinase inhibitor, in healthy volunteers: First-in-human, randomized, ascending-dose studies. Br J Clin Pharmacol. 2025, Mar 14. doi: 10.1002/bcp.70039. Epub ahead of print.
Hayashi K, Fujita T. Targeting PHGDH improves antitumor action of LAT1 inhibitor on pancreatic cancer. Dokkyo Medical Journal. 2025 in press．
Shinoki R, Jikuya R, Nirei T, Fukazawa T, Takizawa H, Hioki M, Kawaura S, Tatenuma T, Noguchi G, Ueno D, Ito Y, Komeya M, Muraoka K, Hasumi H, Kobayashi K, Takiguchi M, Funakoshi K, Makiyama K, Aizawa N, Ito H.Spinal CRH facilitates the micturition reflex via the CRH2 receptor in rats with normal bladder and bladder outlet obstruction. Sci Rep. 2025; 15: 3604.
英文総説
和文総説・その他
2024年
英文原著
Aizawa N, Natsuya H, Fujita T. Changes of the urothelial barrier system in the cyclophosphamide-induced cystitis in rats
by using a newly established "inside-out" urinary bladder preparation. Low Urin Tract Symptoms. 2024; 16: e12538.
Takei GL, Horibata Y, Toyama F, Hayashi K, Morita A, Ouchi M, Fujita T. Hamster spermatozoa incorporate hypotaurine via
TauT for self-protection.Reproduction. 2024; 168: e240022.
Hayashi K, Fujita T, Chida M. ERK5 Activity Prevention Improves the Antitumor Efficacy of Fluvastatin on Thymic
Carcinoma. Anticancer Res. 2024; 44: 2511-2515.
英文総説
Takei GL. Molecular mechanisms of mammalian sperm capacitation, and its regulation by sodium-dependent secondary active
transporters. Reprod Med Biol. 2024; 23: e12614.
和文総説・その他
2023年
英文原著
Hayashi K, Saeki M, Miura K, Yamasaki N, Matsuda M, Shimora H, Nabe T, Shimizu Y, Fujita T, Endou H, Kaminuma O. JPH203,
a LAT1 inhibitor, alleviates steroid-resistant murine airway inflammation mediated by Th17 cells. Allergy. 2023; 78:
2780-2783.
Aizawa N, Fujita T. Comparison of the effects of two anesthetics, isoflurane and urethane, on bladder function in rats.
J Pharmacol Sci. 2023; 152: 144-150.
Takei GL, Ogura Y, Ujihara Y, Toyama F, Hayashi K, Fujita T. Hamster sperm possess functional Na+/Ca2+-exchanger 1: its
implication in hyperactivation. Int. J. Mol. Sci. 2023; 24: 8905.
Hanawa H, Yamada T, Tanaka-Nakadate S, Yamaguchi S, Hamaguchi S, Fujita T. An exploratory study on the development of
drug-induced renal hyperpotassemia in general anesthetized rats. Dokkyo Medical Journal. 2023; 2: 148-157.
Takagi Y, Yamada T, Tanaka-Nakadate S, Fujita T, Yoshihara S. Development of a young rat hyperkalemia model with
decreased renal excretion of potassium. Dokkyo Medical Journal. 2023; 2: 138-147.
英文総説
Otani N, Ouchi M, Mizuta E, Morita A, Fujita T, Anzai N, Hisatome I. Dysuricemia-a new concept encompassing
hyperuricemia and hypouricemia. Biomedicines. 2023; 11: 1255.
Aizawa N, Fujita T. Inhibitory effects of vibegron, a beta(3)-adrenoceptor agonist, on the myogenic contractile and
mechanosensitive afferent activities in an obstructed rat bladder. Eur J Pharmacol. 2022; 933: 175272.
Ouchi M, Morita A, Satoh K, Kobayashi S, Terada M, Kon H, Hayashi K, Suzuki T, Oba K, Sugihara H, Yasutake M, Anzai N,
Fujita T. Effects of 1,5-anhydro-D-glucitol on insulin secretion both in in vitro and ex vivo pancreatic preparations. J
Pharmacol Sci. 2022; 149: 66-72.
Kurosaki Y, Imoto A, Kawakami F, Ouchi M, Morita A, Yokoba M, Takenaka T, Ichikawa T, Katagiri M, Nielsen R, Ishii N. In
vitro study on effect of bardoxolone methyl on cisplatin-induced cellular senescence in human proximal tubular cells.
Mol Cell Biochem. 2022; 477: 689-699.
Owada T, Kurasawa K, Endou H, Fujita T, Anzai N, Hayashi K. LAT1-specific inhibitor ameliorates severe autoimmune
arthritis in SKG mouse. Int Immunopharmacol. 2022; 109: 108817.
Higashi S, Makiyama T, Sakane H, Nogami S, Shirataki H. Regulation of Hook1-mediated endosomal sorting of
clathrin-independent cargo by γ-taxilin. J Cell Sci. 2022:1 35: jcs258849.
Higashi S, Shirataki H. Physicochemical Properties of α-Taxilin as a Putative Tethering Factor. Dokkyo Medical Journal.
2022; 1: 167-175.
英文総説
Hayashi K, Kaminuma O. Therapeutic potential for intractable asthma by targeting L-type amino acid transporter 1.
Biomolecules. 2022 ; 12: 553.
Hayashi K, Anzai N. L-type amino acid transporter 1 as a target for inflammatory disease and cancer immunotherapy. J
Pharmacol Sci. 2022; 148 :3 1-40.
Aizawa N, Fujita T. The TRPM8 channel as a potential therapeutic target for bladder hypersensitive disorders. J Smooth
Muscle Res. 2022; 58: 11-21.
Hayashi K, Nakazato Y, Ouchi M, Fujita T, Endou H, Chida M. Antitumor effect of dimethyl itaconate on thymic carcinoma
by targeting LDHA-mTOR axis. Life Sci. 2021; 282: 119847.
Aizawa N, Fujimori Y, Nakanishi O, Hayashi T, Goi Y, Kobayashi JI, Fujita T. Efficacy of the combination of KPR-5714, a
novel transient receptor potential melastatin 8 (TRPM8) antagonist, and beta3-adrenoceptor agonist or anticholinergic
agent on bladder dysfunction in rats with bladder overactivity. Eur J Pharmacol. 2021; 89: 173995.
Takei GL, Tourzani DA, Paudel B, Visconti PE. Activation of cAMP-dependent phosphorylation pathways is independent of
ROS production during mouse sperm capacitation. Mol. Reprod. Dev. 2021; 88: 544-557.
Takei GL, Kon H. Oviductal high concentration of K+ suppresses hyperpolarization but does not prevent hyperactivation,
acrosome reaction and in vitro fertilization in hamsters. Zygote. 2021; 29: 66-74
Morita A, Ouchi M, Satoh K, Kobayashi S, Terada M, Wakashin H, Kon H, Hayashi K, Anzai N, Shimizu A, Sugihara H, Oba K,
Fujita T. The effects of trypsin inhibitor on insulin secretion using rat pancreas in an organ bath. In Vivo. 2021; 35:
2551-2558.
Yamada T, Kaneko H, Inose C, Tanaka-Nakadate S, Hanawa H, Hamaguchi S, Yamaguchi S, Fujita T. Effect of in-vivo
administration of nafamostat on the onset of renal hyperkalemia and association of urine kallikrein in rats. Dokkyo
Journal of Medical Sciences. 2021; 48: 33-42.
Kamei J, Aizawa N, Nakagawa T, Kaneko S, Fujimura T, Homma Y, Kume H, Igawa Y. Lacking transient receptor potential
melastatin 2 attenuates lipopolysaccharide-induced bladder inflammation and its associated hypersensitivity in mice. Int
J Urol. 2021; 28: 107-114.
Ito D, Miura K, Saeki M, Yamasaki N, Ogata S, Koyama T, Hiroi T, Mori A, Endou H, Hayashi K, Kaminuma O. L-type amino
acid transporter 1 inhibitor suppresses murine Th2 cell-mediated bronchial hyperresponsiveness independently of
eosinophil accumulation. Asia Pac Allergy. 2021; 11: e33.
Betsunoh H, Sakamoto S, Kaji Y, Nukui A, Kobayashi M, Yashi M, Hayashi K, Anzai N, Kamai T. Clinical significance of
18F-fluorodeoxyglucose and glucose transporter 1 mRNA in clear cell renal cell carcinoma. Anticancer Res. 2021; 41:
5179-518
Kamai T, Higashi S, Murakami S, Arai K, Namatame T, Kijima T, Abe H, Jamiyan T, Ishida K, Shirataki H, Yoshida KI.
Single nucleotide variants of succinate dehydrogenase A gene in renal cell carcinoma. Cancer Sci. 2021; 112: 3375-3387.
英文総説
和文総説・その他
2020年
英文原著
Hayashi K, Kaminuma O, Nishimura T, Saeki M, Matsuoka K, Hiroi T, Jutabha P, Iwata Y, Sugiura K, Owada T, Kurasawa K,
Okayasu I, Ouchi M, Fujita T, Kanai Y, Endou H, Anzai N. LAT1-specific inhibitor is effective against T cell-mediated
allergic skin inflammation. Allergy. 2020; 75: 463-467.
Hayashi K, Nakazato Y, Morito N, Sagi M, Fujita T, Anzai N, Chida M. Fluvastatin is effective against thymic carcinoma.
Life Sci. 2020; 240: 117110.
Aizawa N, Yamanishi T, Fujita T. Bladder sensation evaluation of a carrageenan-induced chronic prostatitis model using a
direct measurement of the bladder mechanosensitive single-unit afferent nerve activity. Neurourol Urodyn. 2020; 39:
2111-2119.
Takei GL, Hayashi K. Na+/K+-ATPase α4 regulates sperm hyperactivation while Na+/K+-ATPase α1 regulates basal motility in
hamster spermatozoa. Theriogenology. 2020; 157: 48-60.
Morita A, Ouchi M, Satoh K, Terada M, Kon H, Wakashin H, Hayashi K, Anzai N, Oba K, Shimizu A, Fujita T. Development of
an organ bath technique for isolated rat pancreas preparations to assess the effect of 1,5-AG on insulin secretion.
Experimental Animals. 2020; 69: 127–134.
Yumizaki T, Maeda M, Fujita T, Kakuyama H, Kumagai Y. A 3-part phase 1 study to investigate the safety, tolerability,
pharmacokinetics, and pharmacodynamics of DSP-6952 in healthy Japanese subjects and those with ≤3 spontaneous bowel
movements per week. Clin Pharmacol Drug Dev. 2020; 9: 353-365.
Itou M, Fujita T, Inoue K, Uchida N, Takagaki T, Ishii D, Kakuyama H. Pharmacokinetics and safety of ranirestat in
patients with hepatic impairment. J Clin Pharmacol. 2020; 60: 1397-1403.
Kumagai Y, Fujita T, Maeda M, Sasaki Y, Nagaoka M, Huang J, Takenaka T, Kawai M. A drug-drug interaction study to
evaluate the effect of TAS-303 on CYP3A activity in the small intestine and liver. J Clin Pharmacol. 2020; 60: 702-710.
Masuda K, Aizawa N, Watanabe D, Okegawa T, Kume H, Igawa Y, Fukuhara H. Pathophysiological changes of the lower urinary
tract behind voiding dysfunction in streptozotocin-induced long-term diabetic rats. Sci Rep. 2020; 10: 4182.
Kaminuma O, Nishimura T, Saeki M, Yamasaki N, Ogata S, Fujita T, Endou H, Hayashi K. L-type amino acid transporter 1
(LAT1)-specific inhibitor is effective against T cell-mediated nasal hyperresponsiveness. Allergol Int. 2020; 69:
455-458
Satou M, Wang J, Nakano-Tateno T, Teramachi M, Suzuki T, Hayashi K, Lamothe S, Hao Y, Kurata H, Sugimoto H, Chik C,
Tateno T. L-type amino acid transporter 1, LAT1, in growth hormone-producing pituitary tumor cells. Mol Cell Endocrinol.
2020; 515: 110868
Shimizu Y, Nakamura Y, Horibata Y, Fujimaki M, Hayashi K, Uchida N, Morita H, Arai R, Chibana K, Takemasa A, Sugimoto H.
Imaging of lysophosphatidylcholine in an induced pluripotent stem cell-derived endothelial cell network. Regen Ther.
2020; 14: 299-305
Nakanishi O, Fujimori Y, Aizawa N, Hayashi T, Matsuzawa A, Kobayashi JI, Hirasawa H, Mutai Y, Tanada F, Igawa Y.
KPR-5714, a novel transient receptor potential melastatin 8 antagonist, improves overactive bladder via inhibition of
bladder afferent hyperactivity in rats. J Pharmacol Exp Ther. 2020; 373: 239-247.
Aizawa N, Ohshiro H, Watanabe S, Kume H, Homma Y, Igawa Y. RQ-00434739, a novel TRPM8 antagonist, inhibits prostaglandin
E2-induced hyperactivity of the primary bladder afferent nerves in rats. Life Sci. 2019; 218: 89-95.
Yoshida M, Matsunaga A, Igawa Y, Fujimura T, Shinoda Y, Aizawa N, Sato Y, Kume H, Homma Y, Haga N, Sanada H. May
perioperative ultrasound-guided pelvic floor muscle training promote early recovery of urinary continence after
robot-assisted radical prostatectomy? Neurourol Urodyn. 2019; 38: 158-164.
Satoh K, Ouchi M, Morita A, Kashimata M. MARCKS phosphorylation and amylase release in GLP-1-stimulated acini isolated
from rat pancreas. J Physiol Sci. 2019; 69: 143-149.
Kamata M, Amano H, Ito Y, Fujita T, Otaka F, Hosono K, Kamata K, Takeuchi Y, Yokomizo T, Shimizu T, Majima M. Role of
the high-affinity leukotriene B4 receptor signaling in fibrosis after unilateral ureteral obstruction in mice. PLoS One.
2019; 14: e0202842.
Kamata M, Amano H, Ito Y, Fujita T, Otaka F, Hosono K, Kamata K, Takeuchi Y, Yokomizo T, Shimizu T, Majima M.
Correction: Role of the high-affinity leukotriene B4 receptor signaling in fibrosis after unilateral ureteral
obstruction in mice. PLoS One. 2019; 14: e0215625.
Fujimura T, Igawa Y, Aizawa N, Niimi A, Yamada Y, Sugihara T, Kamei J, Sato Y, Matsunaga A, Yoshida M, Shinoda Y,
Fukuhara H, Nakagawa T, Homma Y, Kume H. Longitudinal change of comprehensive lower urinary tract symptoms and various
types of urinary incontinence during robot-assisted radical prostatectomy. Neurourol Urodyn. 2019; 38: 1067-1075.
Yamaguchi Y, Kamai T, Higashi S, Murakami S, Arai K, Shirataki H, Yoshida KI. Nrf2 gene mutation and single nucleotide
polymorphism rs6721961 of the Nrf2 promoter region in renal cell cancer. BMC Cancer. 2019; 19:1137.
英文総説
Igawa Y, Aizawa N, Michel MC. β3 -Adrenoceptors in the normal and diseased urinary bladder-What are the open questions?
Br J Pharmacol. 2019; 176: 2525-2538.